PKM2 activator 2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PKM2 activator 2 是一种具有抗增殖作用的丙酮酸激酶 M2 (PKM2) 激活剂，AC50 为 66 nM。PKM2 activator 2 可能具有抗肿瘤增殖作用，并缓解 Warburg 效应，因为 PKM2 激活可使细胞恢复正常糖酵解代谢状态。

PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells.

PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines .PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC50 value of 66 nM in the luciferase-coupled assay.

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Others

Other Targets

PKM

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1186660-06-9

452.49

C20H18F2N2O4S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 5 mg/mL (11.05 mM; 超声助溶 (<60°C)

Fc1cccc(F)c1S(=O)(=O)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1

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(-20℃)

With Ice Pack

≥ 2 years